49ers vs. Bears Week 1 Prediction and Odds - Sep 11, 2022

Updated: Dec 21, 2023, 8:18 AM ET | First published: May 20, 2022, 2:20 AM ET

Written by Kevin Hansen, Senior Sports Analyst

49ers vs. Bears Week 1 Prediction and Odds - Sep 11, 2022

The Chicago Bears take on the favored San Francisco 49ers in NFL Week 1 action at Soldier Field on Sunday, starting at 1:00PM ET.

Dimers' best betting picks for 49ers vs. Bears, as well as our score prediction, betting odds and projected player stats, are detailed below.

Today's San Francisco vs. Chicago betting preview is presented by FanDuel Sportsbook, which has an outstanding Bet $5, Win $150 offer for new users.

Who will win 49ers vs. Bears?

Based on state-of-the-art computer power and data, Dimers.com has simulated Sunday's 49ers-Bears NFL game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the 49ers a 75% chance of defeating the Bears in Week 1 of the NFL season.

More: 49ers vs. Bears Simulated 10K Times

49ers vs. Bears Odds

Spread: Bears +6 (-105), 49ers -6 (-115)
Moneyline: Bears +240, 49ers -260
Total: Over/Under 38 (-107/-107)

Point Spread, Moneyline and Over/Under

The Bears are currently +6 underdogs versus the 49ers, with -105 at DraftKings Sportsbook the best odds currently available.

For the favored 49ers (-6) to cover the spread, DraftKings Sportsbook also has the best odds currently on offer at -115.

BetMGM currently has the best moneyline odds for the Bears at +240, which means you can bet $100 to profit $240, earning a total payout of $340, if they win.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -260, where you can risk $260 to win $100, for a total payout of $360, if they come out on top.

The Over/Under sits at 38 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, check out all of the sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-6) are a 54% chance of covering the spread, while the 38-point Over/Under is a 53% chance of going Over.

More: Free Online Bet Tracker

Best Bets for 49ers vs. Bears

Spread: 49ers -6 @ -115 via DraftKings Sportsbook (54% probability)
Moneyline: 49ers @ -260 via DraftKings Sportsbook (75% probability)
Total: Over 38 @ -107 via PointsBet (53% probability)

Dimers' best bets are based on world-class modeling and betting intelligence to help you make better investments with your state's legal sportsbooks.

49ers vs. Bears Prediction

Dimers.com's predicted final score for San Francisco vs. Chicago at Soldier Field in Week 1 has the 49ers winning 22-16.

Click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's 49ers-Bears matchup in Week 1, including pregame predictions, computer picks, and live win probabilities.

49ers vs. Bears Player Props

Who will score an anytime touchdown in 49ers vs. Bears? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Bears, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Sunday's game.

According to DimersBOT, San Francisco's Elijah Mitchell is most likely to score the first TD in 49ers vs. Bears.

DimersBOT gives Mitchell a 10.7% chance of getting in for six first at Soldier Field, while the 49ers RB is a 40.3% chance of scoring an anytime touchdown.

Scroll down for our complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

San Francisco 49ers

Elijah Mitchell: 10.7% probability
Deebo Samuel: 10.5% probability
Trey Lance: 8.4% probability
Brandon Aiyuk: 7.6% probability
Jauan Jennings: 4.9% probability

Chicago Bears

David Montgomery: 9.0% probability
Justin Fields: 6.4% probability
Darnell Mooney: 5.8% probability
Cole Kmet: 5.7% probability
Equanimeous St. Brown: 4.1% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

Elijah Mitchell: 40.3% probability
Deebo Samuel: 39.2% probability
Trey Lance: 33.2% probability
Brandon Aiyuk: 30.3% probability
Jauan Jennings: 20.2% probability

Chicago Bears

David Montgomery: 35.4% probability
Justin Fields: 27.0% probability
Darnell Mooney: 25.4% probability
Cole Kmet: 23.6% probability
Equanimeous St. Brown: 17.5% probability

49ers-Bears Projected Player Stats

Of the starting quarterbacks, the 49ers' Trey Lance is projected for 204 passing yards. The Bears' Justin Fields is expected to throw for 216 yards.

49ers Starting QB

Trey Lance: 204 projected yards

Bears Starting QB

Justin Fields: 216 projected yards

49ers Rushing

Elijah Mitchell: 74 projected yards
Trey Lance: 39 projected yards
Deebo Samuel: 27 projected yards

Bears Rushing

David Montgomery: 54 projected yards
Justin Fields: 38 projected yards
Khalil Herbert: 24 projected yards

49ers Receiving

Deebo Samuel: 60 projected yards
Brandon Aiyuk: 52 projected yards
Jauan Jennings: 28 projected yards
Tyler Kroft: 20 projected yards
Kyle Juszczyk: 18 projected yards

Bears Receiving

Darnell Mooney: 60 projected yards
Cole Kmet: 41 projected yards
Equanimeous St. Brown: 41 projected yards
Byron Pringle: 32 projected yards
David Montgomery: 23 projected yards

Don't forget, DimersBOT updates frequently, so refresh this article for the latest betting analysis ahead of 49ers vs. Bears on Sunday September 11, 2022.

49ers vs. Bears 2022

The NFL Week 1 action between the Bears and 49ers at Soldier Field is scheduled to commence at 1:00PM ET.

Who: San Francisco 49ers vs. Chicago Bears
Date: Sunday September 11, 2022
Time: 1:00PM ET / 10:00AM PT
Venue: Soldier Field

Ready to join an online sportsbook and start betting on the NFL now? We've listed the best available sign-up offers for each legal betting state.

What NFL games are on today?

The 49ers and Bears aren't the only two NFL teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every NFL matchup via our NFL Predictions section.

Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!

Written by

Kevin Hansen

Senior Sports Analyst

Kevin Hansen specializes in NFL, NBA, MLB, and NHL content, using data-driven insights for sports betting. He provides simple, actionable betting tips to help bettors find an edge and pick winners.

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49ers vs. Bears Week 1 Prediction and Odds - Sep 11, 2022

Who will win 49ers vs. Bears?