Padres vs. Tigers Prediction: Detroit Predicted to Win Monday's MLB Matchup [4/21/2025]

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Written by Jason Bevilacqua

Our expert prediction for Monday's San Diego Padres vs Detroit Tigers matchup.

San Diego Padres-Detroit Tigers Predictions and Game Preview.
Comerica Park sets the stage for the MLB matchup between the San Diego Padres and Detroit Tigers this Monday.

MLB action continues on Monday at 6:40PM ET as the San Diego Padres take on the Detroit Tigers at Comerica Park.

Keider Montero (0-1, 9.00 ERA) will be on the bump for the Tigers, up against Randy Vásquez (1-1, 1.74 ERA) for the Padres.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's San Diego-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Tigers are likely to win, with a probability of 53%, compared to the Padres' 47%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Padres vs. Tigers predictions page.

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Padres vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB game between the Padres and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Tigers a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities
Last Updated: 9:30PM, Apr 21
Moneyline
Over / Under
Run Line
Padres
Win %
47%
53%
Get the best bets with Dimers Pro
See Matchup
Tigers
Padres SD
Win %
47%
53%
See Matchup
Tigers DET
Randy Vásquez 1-1, 1.74 ERA
Keider Montero 0-1, 9.00 ERA
Get the best bets with Dimers Pro

Padres vs. Tigers Odds [4/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Padres Tigers
Run Line +1.5 (-175) -1.5 (+154)
Moneyline +125 -135
Total o8.5 (-105) u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Tigers Picks and Best Bets

Our model's strongest edge in today's Padres vs. Tigers matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Padres vs. Tigers Game-Day Updates and Essential Details

Monday's MLB action between the Tigers and Padres at Comerica Park is scheduled to commence at 6:40PM ET.

Dimers.com's in-depth preview of Monday's Padres vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Tigers, with a 53% win probability, will likely beat the Padres on Monday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date projections for the World Series, American League, National League and each division.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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