Padres vs. Tigers Prediction: Detroit Predicted to Win Monday's MLB Matchup [4/21/2025]

MLB action continues on Monday at 6:40PM ET as the San Diego Padres take on the Detroit Tigers at Comerica Park.

Keider Montero (0-1, 9.00 ERA) will be on the bump for the Tigers, up against Randy Vásquez (1-1, 1.74 ERA) for the Padres.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's San Diego-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Tigers are likely to win, with a probability of 53%, compared to the Padres' 47%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Padres vs. Tigers predictions page.

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Padres vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB game between the Padres and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Tigers a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 9:30PM, Apr 21

Moneyline

Over / Under

Run Line

Padres

Win %

47%

53%

+125

-135

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Tigers

Padres SD

+125

Win %

47%

53%

See Matchup

Tigers DET

-135

Randy Vásquez 1-1, 1.74 ERA

Keider Montero 0-1, 9.00 ERA

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Padres vs. Tigers Odds [4/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Padres vs. Tigers Picks and Best Bets

Our model's strongest edge in today's Padres vs. Tigers matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

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Padres vs. Tigers Game-Day Updates and Essential Details

Monday's MLB action between the Tigers and Padres at Comerica Park is scheduled to commence at 6:40PM ET.

• Who: San Diego Padres vs. Detroit Tigers
• Date: Monday, April 21, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Monday's Padres vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 53% win probability, will likely beat the Padres on Monday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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