Yankees vs. Guardians Prediction: Cleveland Predicted to Win Monday's MLB Matchup [4/21/2025]

The Cleveland Guardians and New York Yankees are scheduled to meet in MLB action at Progressive Field on Monday, starting at 6:10PM ET.

The Guardians will have Gavin Williams (1-1, 4.58 ERA) as their starting pitcher, while the Yankees will counter with Clarke Schmidt (0-0, 4.76 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's NY Yankees-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Guardians are likely to win, with a probability of 51%, compared to the Yankees' 49%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Yankees vs. Guardians predictions page.

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Yankees vs. Yankees Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Yankees and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Guardians a 51% chance of beating the Yankees.

According to our model, the Guardians (+1.5) have a 64% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:29PM, Apr 21

Moneyline

Over / Under

Run Line

Yankees

Win %

49%

51%

-124

+110

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See Matchup

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Guardians

Yankees NYY

-124

Win %

49%

51%

See Matchup

Guardians CLE

+110

Clarke Schmidt 0-0, 4.77 ERA

Gavin Williams 1-1, 4.58 ERA

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Yankees vs. Guardians Odds [4/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Yankees vs. Guardians matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

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Yankees vs. Guardians Game-Day Updates and Essential Details

Monday's MLB action between the Guardians and Yankees at Progressive Field is scheduled to start at 6:10PM ET.

• Who: New York Yankees vs. Cleveland Guardians
• Date: Monday, April 21, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Monday's Yankees vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any NY Yankees vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 51% win probability, will likely beat the Yankees on Monday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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