College Basketball and March Madness Picks Today: Wednesday's Best Bets Include Two Spread Plays [3/19/2025]

College basketball betting is back for another enticing slate on 3/19, and we're here to serve up our top picks for Wednesday's NCAAM action, with our model working hard to find bets in the March Madness tournament and elsewhere.

Today's college basketball best bets come from a range of matchups, including Loyola Chicago vs. San Jose State and Utah Valley vs. San Francisco, with this article updated throughout the day to highlight the most attractive upcoming games.

Led by a standout spread play at 11:00PM ET, these picks are based on advanced simulations and machine learning.

For unlimited access to everything Dimers has to offer on Wednesday, March 19, 2025—including our complete set of March Madness picks and best bets—check out Dimers Pro.

Get 20% off Dimers Pro With Code 20BASKETBALL

Get Dimers Pro

Sign up with code 20BASKETBALL at checkout now to get 20% off your first month of Dimers Pro! Perfect timing for the playoffs.

List of College Basketball Picks Tonight [3/19, Updated: 10:31PM ET]

After crunching the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best college basketball bets for Wednesday, March 19, 2025.

We sort these picks by start times, reserving the highest edges and probabilities exclusively for Dimers Pro users.

San Jose State +3.5 (-105)

• Edge: 4.6%
• Probability: 55.8%
• Matchup: Loyola Chicago vs. San Jose State (11:00PM ET, Wednesday)

Our model has pinpointed the next college basketball betting opportunity tonight, which comes in the Loyola Chicago vs. San Jose State matchup. We recommend a spread bet on San Jose State +3.5 at -105 odds, offering an edge of 4.6%.

San Jose State +3.5 vs. Loyola Chicago

-105

Bet $25
Payout $48.80Bet $25, Payout $48.80

San Francisco -6.5 (-105)

• Edge: 3.8%
• Probability: 55%
• Matchup: Utah Valley vs. San Francisco (11:00PM ET, Wednesday)

Our model has found another great college basketball bet for Wednesday's NCAA action, this time in the matchup between Utah Valley and San Francisco. We suggest placing a spread wager on San Francisco -6.5 at -105 odds, with our analysis showing a compelling 3.8% edge.

San Francisco -6.5 vs. Utah Valley

-105

Bet $25
Payout $48.80Bet $25, Payout $48.80

MORE: March Madness Props

San Francisco ML (-255)

• Edge: 3.3%
• Probability: 75.2%
• Matchup: Utah Valley vs. San Francisco (11:00PM ET, Wednesday)

Our next pick for today's college basketball action is also from the Utah Valley vs. San Francisco game. We recommend a bet on San Francisco ML at -255 odds. Our model indicates a favorable 3.3% edge for this wager.

San Francisco ML vs. Utah Valley

-255

Bet $25
Payout $34.80Bet $25, Payout $34.80

MORE: Wednesday Parlay Picker

NCAAM Best Bets: Wednesday, 3/19/2025

As of 10:31PM ET, here are the next three college basketball bets recommended by our model:

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.

While the bets listed are all positive expected value (+EV) opportunities, subscribing to Dimers Pro grants you instant access to today's best bets across all sports, powered by our advanced model.

Wednesday's full suite of NCAAM picks is highlighted by an over/under opportunity with a substantial 7.4% edge over the sportsbook odds.

Join Dimers Pro now to access these picks, along with a comprehensive range of props, trends and parlays for March 19, 2025.

Get 20% off Dimers Pro With Code 20BASKETBALL

Get Dimers Pro

List of Upcoming College Basketball Games To Bet On

• Loyola Chicago vs. San Jose State (11:00PM ET, Wednesday)
• Utah Valley vs. San Francisco (11:00PM ET, Wednesday)
• Creighton vs. Louisville (12:15PM ET, Thursday)
• High Point vs. Purdue (12:40PM ET, Thursday)
• Montana vs. Wisconsin (1:30PM ET, Thursday)
• SIU-Edwardsville vs. Houston (2:00PM ET, Thursday)
• Alabama State vs. Auburn (2:50PM ET, Thursday)
• McNeese State vs. Clemson (3:15PM ET, Thursday)
• Virginia Commonwealth vs. BYU (4:05PM ET, Thursday)
• Georgia vs. Gonzaga (4:35PM ET, Thursday)

More About CBB

This article is part of our college basketball player props and college basketball best bets series.

For more NCAAB betting content, we have college basketball betting news and the latest March Madness odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.