Clemson vs. Louisville Prediction: Clemson Predicted to Win College Basketball Matchup [3/14/2025]

Louisville and Clemson will lock horns in college basketball action at Spectrum Center on Friday, with tipoff at 9:30PM ET.

Based on updated simulations, Dimers' advanced college basketball model (see Dimers Pro for full access) predicts Clemson as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Employing the latest data, our experts simulated Friday's Clemson-Louisville game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict Clemson's chance of winning is 59%, while Louisville's is 41%."

For further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Clemson vs. Louisville predictions page.

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Clemson vs. Louisville Prediction: Who Will Win, Cover the Spread?

Using powerful machine learning and data, we have simulated the result of Friday's NCAA basketball game between Clemson and Louisville 10,000 times as part of our college basketball predictions coverage.

Our independent predictive model currently gives Clemson a 59% chance of defeating Louisville. Our predicted final score has Clemson winning 73-70.

According to our model, Louisville (+2.5) has a 51% chance of covering the spread, while the 141.5-point over/under has a 54% chance of going over.

Clemson vs. Louisville Odds

We have researched the best College Basketball odds in America for this game, which are listed here:

Bet Type	Clemson	Louisville
Spread	-2.5 (-105)	+2.5 (-110)
Moneyline	-138	+120
Total	o141.5 (-110)	u141.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Clemson vs. Louisville Picks and Best Bets

Our model's strongest edge in today's Clemson vs. Louisville matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Clemson vs. Louisville Game-Day Updates and Essential Details

Friday's college basketball action between Louisville and Clemson at Spectrum Center is scheduled to begin at 9:30PM ET.

• Who: Clemson vs. Louisville
• Date: Friday, March 14, 2025
• Time: 9:30PM ET/6:30PM PT
• Venue: Spectrum Center

Dimers.com's full preview of Friday's Clemson vs. Louisville matchup includes our prediction, picks and the latest betting odds.

Before making any Clemson vs. Louisville picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Clemson, with a 59% win probability, will likely beat Louisville on Friday.

AI and automation have enhanced this article to quickly deliver accurate Clemson vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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