Francisco Comesana vs. Flavio Cobolli prediction, odds, picks for US Open 2026

Francisco Comesana will take on Flavio Cobolli in the first round of the US Open Men's Singles 2026 on Tuesday.

Dimers' proven tennis model projects Flavio Cobolli as the most likely winner in this Comesana vs. Cobolli prediction.

This article offers further insights into Tuesday's match, including best bets and picks.

Comesana vs. Cobolli prediction: Who will win and advance to the second round?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's Comesana-Cobolli men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model currently gives Cobolli a 79% chance of defeating Comesana in the US Open 2026.

Francisco Comesana vs. Flavio Cobolli odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Flavio Cobolli -450, Francisco Comesana +390

All odds are correct at the time of publication and are subject to change.

Comesana vs. Cobolli picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Comesana @ +390 via DraftKings
• First Set: Cobolli @ -125 via DraftKings

According to our best tennis bets, the top play to make on this match is Francisco Comesana to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Comesana vs. Cobolli updates and essential details

The US Open 2026 match between Francisco Comesana and Flavio Cobolli is scheduled to begin on Tuesday at 11:00 AM ET.

• Who: Francisco Comesana vs. Flavio Cobolli
• Date: Tuesday, September 1, 2026
• Approx. Time: 11:00 AM ET/8:00AM PT
• Tournament: US Open Men's Singles 2026
• Round: First round

All dates and times in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Flavio Cobolli, with a 79% win probability, will likely beat Francisco Comesana at the US Open 2026.

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