Lions vs. Bills: NFL Week 2 Prediction, Picks & Odds
Spread
- Lions
- Bills
- Jahmyr Gibbs76.8%
- Amon-Ra St. Brown41.3%
- Jameson Williams32.4%
- Sam LaPorta
- Sione Vaki
- James Cook54.5%
- Josh Allen45.4%
- DJ Moore36.7%
- Dalton Kincaid
- Khalil Shakir
| Player | Proj. Yards |
|---|---|
| J. Goff |
| Player | Proj. Yards |
|---|---|
| J. Allen |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| J. Gibbs | ||
| S. Vaki | ||
| J. Goff |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| J. Cook | ||
| J. Allen | ||
| R. Davis |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| A. St. Brown | ||
| J. Williams | ||
| S. LaPorta | ||
| J. Gibbs | ||
| I. TeSlaa |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| D. Moore | ||
| D. Kincaid | ||
| K. Shakir | ||
| J. Palmer | ||
| J. Cook |
Lions vs. Bills: Detailed Breakdown
Matchup overview: NFL Week 2
- Teams: Detroit Lions vs. Buffalo Bills
- Date: Thursday, September 17, 2026
- Time: 8:15PM ET
- Venue: Highmark Stadium
Current betting odds
- Spread: Lions (+4.5, +100), Bills (-4.5, -104)
- Moneyline: Lions +199, Bills -203
- Total (Over/Under): 53.5 points (-104/+100)
Dimers’ win probabilities
- Lions: 34.1%
- Bills: 65.9%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Lions 23-28 Bills.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Lions a win probability of 34.1%, while the Bills have a win probability of 65.9%.
Summary
The Lions face off against the Bills in the NFL at Highmark Stadium on Thursday, September 17, 2026.
Our Lions vs. Bills predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling please call 1-800-GAMBLER.
When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.
For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.