NFL Same Game Parlay Picks: Bills vs. 49ers SGP for Sunday Night Football Week 13

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Sunday Night Football is here once again, this time featuring a cross-coast battle between the Buffalo Bills and San Francisco 49ers, and we're closing out Week 13's Sunday slate with our latest Primetime Parlay powered by the DimersBOT, this one at +750 odds.

The 49ers are in dire need of a win to close the gap in the postseason race as they currently sit outside the bubble and they'll need to contend with a long road trip and cold weather on top of a battle with the tenacious Bills. Now, let's start the month with a parlay cash!

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+750 Buffalo Bills vs. San Francisco 49ers NFL Same Game Parlay Picks

After simulating tonight's game over 10,000 times, our model has identified the following projections and probabilities for the picks that make up our Same Game Parlay in Bills vs. 49ers on Primetime, Sunday Night Football.

MORE: Buffalo Bills vs. San Francisco 49ers Full Game Betting Preview

Leg 1: Christian McCaffrey Over 59.5 Rush Yards (-120)

Our first leg of this parlay is on 49ers running back Christian McCaffrey to clear his rushing line of 59.5 yards. He's played three games since returning from a preseason Achilles tendinitis issue that kept him out of the team's first 8 games. Since returning he's cleared this mark once with 79 rushing yards in his second game back.

His first game leaned heavily towards the passing game, while last week was a 38-10 blowout loss to the Packers with backup QB Brandon Allen starting. This week, while a tough test, should be his most "normal" game yet - four weeks removed from injury and with his starting QB ideally playing.

The Bills have a solid rushing defense this year, but are still allowing 82.2 rushing yards to RBs (middle of the league) and McCaffrey is as good as there is. We project McCaffrey for 81.1 yards on the ground with a 71.3% probability to go over.

Leg 2: James Cook Over 64.5 Rush Yards (-115)

Let's switch backfields for our next leg and take Bills RB James Cook to clear his line as well. 

Cook has hit this five times this year, three times in his past six games. Volume is critical for him - he's only hit it once in games with fewer than 15 carries, and clearing it in every game he's gone over that touch total. He should see solid volume in this game - his Rush Attempts line is set at 15.5 and the 49ers have one of the best passing defenses in the NFL, while they've been just fine against the run, allowing 91.2 yards per game to running backs.

They've seen four of the past six RB1s they've faced go over this line, six total times this season, and there's a trend - the bad teams go under and the good ones go over. We project Cook for 70.4 in this game, not crushing this line, but going over.

Leg 3: Josh Allen Anytime TD (+130)

As always, we close out with our TD prop of the night. It's our second-highest probability in this game and it's Josh Allen to rush one in.

Allen has scored five TDs on the ground this season and has done so in back-to-back weeks. The 49ers are very stingy to QBs but Josh Allen is a 1-of-1 and may find himself rushing more than usual against a stout 49ers pass defense.

He's got a little bit of extra motivation this week - the man just got engaged over the bye week! It's not a data-powered metric, but the intangible things that make players play just a little harder can come into play; they are human after all.

Allen gets a 41.4% probability to score from our model, which would make fair odds of +140, just about where we're getting him at +130 in this one.

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