NFL Best Bets: Week 13 Picks Include 49ers vs. Bills Play [12/1/2024]

NFL betting is back for another great day, and we're here to serve up our top picks for Sunday's football action.

Today's NFL best bets come from a range of matchups, including the 49ers vs. Bills game at 8:20PM ET, with updates coming throughout the day to focus on upcoming games.

Led by an over/under play at 8:20PM ET, these bets are based on extensive simulations and machine learning.

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List of NFL Best Bets Tonight [12/1/2024]

After crunching the numbers and running thousands of simulations, our independent predictive analytics model has identified the best football bet for Sunday, December 1, 2024.

This is the only pick available for free users currently, with our full suite of NFLpredictions reserved for Dimers Pro users.

49ers vs. Bills Over 44.5 Points (-110)

• Edge: 2.2%
• Probability: 54.6%
• Matchup: 49ers vs. Bills (8:20PM ET, Sunday)

Our model has pinpointed the next NFL betting opportunity tonight, which comes in the 49ers vs. Bills game. We recommend an over/under bet on Over 44.5 Points at -110 odds, offering an edge of 2.2%.

NFL Best Bets: Sunday, 12/1/2024

As of 4:01PM ET, here are the next NFL bets recommended by our model:

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List of Upcoming NFL Games to Bet On [12/1/2024]

• Buccaneers vs. Panthers (4:05PM ET, Sunday)
• Rams vs. Saints (4:05PM ET, Sunday)
• Eagles vs. Ravens (4:25PM ET, Sunday)
• 49ers vs. Bills (8:20PM ET, Sunday)

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More About NFL

This article is part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.